I'm running it with a Sprint 8130 (CDMA) and it is working fine. I haven't played with the media sync since I use a Nano, but it seems to sync contacts, calendar, etc. a little faster.
One thing to be aware of is that you have to have an Internet connection available before you can sync with the Desktop Manager 4.5 for the first time. I was a little concerned at first since I tether my 8130 to access the internet and with Sprint Connection Manager, the Desktop Manager closes automatically. After I connected to the internet I clicked the Desktop Manager Icon and it opened up and checked for updates. After that I was able to connect and sync without a problem.
I didn't have any trouble downloading and installing DM 4.5. I downloaded the one with the media manager (192 MB) in English. The only thing I had to do is allow the set-up to remove the old roxio data.