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Article: iPhone 5 - Will It Look Like This?
I think the design will remain the same. I think it will be extremely hard to think of something new AND better. I think they went away from the curved backing and they will stay away from it; although the aluminum backing does look pretty sweet!
The antenna at the top back sounds good too. Hopefully there's no issues with that this time around!
I think the changes will be in user experience. Not sure how they'll do this but that's just a hunch.